S19-01 Planarians, stem cells, and regeneration
نویسندگان
چکیده
منابع مشابه
S19-01 Planarians, stem cells, and regeneration
ical role in regulating their entry into the myogenic programme. We had shown that in the Pax3/7 double mutant the myogenic determination genes, Myf5 and MyoD are not activated, leading to a major deficit in skeletal muscle. Pax3 directly activates Myf5, thus promoting a myogenic cell fate. However, it is essential to maintain a balance between differentiation and renewal of the progenitor cell...
متن کاملStem cells and regeneration in planarians.
Understanding stem cells is a major goal of current research because of its potential medical applications. Although great advances have been made, such as the culturing and differentiation of embryonic stem cells and reprogramming of cell fates, many basic questions remain unanswered. Describing the mechanisms underlying regeneration will help to understand the biology of stem cells and theref...
متن کاملRegeneration of Brain and Dopaminergic Neurons Utilizing Pluripotent Stem Cells: Lessons from Planarians
Cell-transplantation therapy for Parkinson’s disease is close to becoming a reality thanks to the recent development of methods for the differentiation of dopaminergic neurons and/or dopaminergic progenitor cells from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) under in vitro conditions (Kawasaki et al., 2000, Perrier et al., 2004). There have been several reports con...
متن کاملRegeneration and pattern formation in planarians III. Evidence that neoblasts are totipotent stem cells and the source of blastema cells
In most regenerating systems, blastema cells arise by dedifferentiation of functional tissue cells. In planarians, though, it is still debatable whether dedifferentiated cells or a population of undifferentiated cells, the neoblasts, are the main source of blastema cells. Moreover, it is unclear whether in the intact organisms neoblasts are quiescent cells 'reserved' for regeneration or if they...
متن کاملRegeneration and pattern formation in planarians
In planarians, blastema cells do not divide, and growth of blastema is thought to result from the steady accumulation, beneath the wound epithelium, of undifferentiated cells produced by cell division in the stump. However, whether these cells come only from local stump sources or whether cells placed far from the wound can also participate, after long-range migrations, in the growth of blastem...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.1092